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10.1096/fj.14-252411 http://scihub22266oqcxt.onion/10.1096/fj.14-252411 C4202098!4202098 !25002123     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25002123 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25002123 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FASEB+J 2014 ; 28 (10 ): 4457-69 Nephropedia Template TP {{tp|p=25002123 |t=2014. Evidence for compartmentalization of mammalian carotenoid metabolism |pdf=|usr=}}{{25002123 }} gab.com Text Evidence for compartmentalization of mammalian carotenoid metabolism JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=25002123 #FOAvip The critical role of retinoids (vitamin A and its derivatives) for vision, reproduction, and survival has been well established. Vitamin A is produced from dietary carotenoids such as ?-carotene by centric cleavage via the enzyme BCO1. The biochemical and molecular identification of a second structurally related ?-carotene metabolizing enzyme, BCO2, has led to a prolonged debate about its relevance in vitamin A biology. While BCO1 cleaves provitamin A carotenoids, BCO2 is more promiscuous and also metabolizes nonprovitamin A carotenoids such as zeaxanthin into long-chain apo-carotenoids. Herein we demonstrate, in cell lines, that human BCO2 is associated with the inner mitochondrial membrane. Different human BCO2 isoforms possess cleavable N-terminal leader sequences critical for mitochondrial import. Subfractionation of murine hepatic mitochondria confirmed the localization of BCO2 to the inner mitochondrial membrane. Studies in BCO2-knockout mice revealed that zeaxanthin accumulates in the inner mitochondrial membrane; in contrast, ?-carotene is retained predominantly in the cytoplasm. Thus, we provide evidence for a compartmentalization of carotenoid metabolism that prevents competition between BCO1 and BCO2 for the provitamin and the production of noncanonical ?-carotene metabolites. Twit Text FOAVip Evidence for compartmentalization of mammalian carotenoid metabolism ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=25002123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25002123 #FOAvip English Wikipedia <ref>{{Cite pmid|25002123 }}</ref> Evidence for compartmentalization of mammalian carotenoid metabolism #MMPMID25002123 Palczewski G ; Amengual J ; Hoppel CL ; von Lintig J FASEB J 2014[Oct]; 28 (10 ): 4457-69 PMID25002123 show ga The critical role of retinoids (vitamin A and its derivatives) for vision, reproduction, and survival has been well established. Vitamin A is produced from dietary carotenoids such as ?-carotene by centric cleavage via the enzyme BCO1. The biochemical and molecular identification of a second structurally related ?-carotene metabolizing enzyme, BCO2, has led to a prolonged debate about its relevance in vitamin A biology. While BCO1 cleaves provitamin A carotenoids, BCO2 is more promiscuous and also metabolizes nonprovitamin A carotenoids such as zeaxanthin into long-chain apo-carotenoids. Herein we demonstrate, in cell lines, that human BCO2 is associated with the inner mitochondrial membrane. Different human BCO2 isoforms possess cleavable N-terminal leader sequences critical for mitochondrial import. Subfractionation of murine hepatic mitochondria confirmed the localization of BCO2 to the inner mitochondrial membrane. Studies in BCO2-knockout mice revealed that zeaxanthin accumulates in the inner mitochondrial membrane; in contrast, ?-carotene is retained predominantly in the cytoplasm. Thus, we provide evidence for a compartmentalization of carotenoid metabolism that prevents competition between BCO1 and BCO2 for the provitamin and the production of noncanonical ?-carotene metabolites. |Amino Acid Sequence [MESH] |Animals [MESH] |Cytoplasm/*metabolism [MESH] |Dioxygenases/chemistry/genetics/metabolism [MESH] |Hep G2 Cells [MESH] |Humans [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mitochondrial Membranes/*metabolism [MESH] |Molecular Sequence Data [MESH] |Protein Sorting Signals [MESH] |Zeaxanthins/*metabolism [MESH] |beta Carotene/*metabolism [MESH]Evidence for compartmentalization of mammalian carotenoid metabolism (epmc).pdf DeepDyve Pubget Overpricing