Evasion of Neutrophil Killing by Staphylococcus aureus
#MMPMID26999220
McGuinness WA
; Kobayashi SD
; DeLeo FR
Pathogens
2016[Mar]; 5
(1
): ? PMID26999220
show ga
Staphylococcus aureus causes many types of infections, ranging from
self-resolving skin infections to severe or fatal pneumonia. Human innate immune
cells, called polymorphonuclear leukocytes (PMNs or neutrophils), are essential
for defense against S. aureus infections. Neutrophils are the most prominent cell
type of the innate immune system and are capable of producing non-specific
antimicrobial molecules that are effective at eliminating bacteria. Although
significant progress has been made over the past few decades, our knowledge of S.
aureus-host innate immune system interactions is incomplete. Most notably, S.
aureus has the capacity to produce numerous molecules that are directed to
protect the bacterium from neutrophils. Here we review in brief the role played
by neutrophils in defense against S. aureus infection, and correspondingly,
highlight selected S. aureus molecules that target key neutrophil functions.
free
free
free
