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2014 ; 11
(10
): 1058-63
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Evaluation and statistical inference for human connectomes
#MMPMID25194848
Pestilli F
; Yeatman JD
; Rokem A
; Kay KN
; Wandell BA
Nat Methods
2014[Oct]; 11
(10
): 1058-63
PMID25194848
show ga
Diffusion-weighted imaging coupled with tractography is currently the only method
for in vivo mapping of human white-matter fascicles. Tractography takes diffusion
measurements as input and produces the connectome, a large collection of
white-matter fascicles, as output. We introduce a method to evaluate the evidence
supporting connectomes. Linear fascicle evaluation (LiFE) takes any connectome as
input and predicts diffusion measurements as output, using the difference between
the measured and predicted diffusion signals to quantify the prediction error. We
use the prediction error to evaluate the evidence that supports the properties of
the connectome, to compare tractography algorithms and to test hypotheses about
tracts and connections.