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10.1038/s41598-017-10633-2 http://scihub22266oqcxt.onion/10.1038/s41598-017-10633-2 C5591286!5591286 !28887462     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28887462 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28887462 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 11038 Nephropedia Template TP {{tp|p=28887462 |t=2017. Evaluating strategies for reversing CRISPR-Cas9 gene drives |pdf=|usr=}}{{28887462 }} gab.com Text Evaluating strategies for reversing CRISPR-Cas9 gene drives JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28887462 #FOAvip A gene drive biases inheritance of a gene so that it increases in frequency within a population even when the gene confers no fitness benefit. There has been renewed interest in environmental releases of engineered gene drives due to recent proof of principle experiments with the CRISPR-Cas9 system as a drive mechanism. Release of modified organisms, however, is controversial, especially when the drive mechanism could theoretically alter all individuals of a species. Thus, it is desirable to have countermeasures to reverse a drive if a problem arises. Several genetic mechanisms for limiting or eliminating gene drives have been proposed and/or developed, including synthetic resistance, reversal drives, and immunizing reversal drives. While predictions about efficacy of these mechanisms have been optimistic, we lack detailed analyses of their expected dynamics. We develop a discrete time model for population genetics of a drive and proposed genetic countermeasures. Efficacy of drive reversal varies between countermeasures. For some parameter values, the model predicts unexpected behavior including polymorphic equilibria and oscillatory dynamics. The timing and number of released individuals containing a genetic countermeasure can substantially impact outcomes. The choice among countermeasures by researchers and regulators will depend on specific goals and population parameters of target populations. Twit Text FOAVip Evaluating strategies for reversing CRISPR-Cas9 gene drives ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28887462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28887462 #FOAvip English Wikipedia <ref>{{Cite pmid|28887462 }}</ref> Evaluating strategies for reversing CRISPR-Cas9 gene drives #MMPMID28887462 Vella MR ; Gunning CE ; Lloyd AL ; Gould F Sci Rep 2017[Sep]; 7 (1 ): 11038 PMID28887462 show ga A gene drive biases inheritance of a gene so that it increases in frequency within a population even when the gene confers no fitness benefit. There has been renewed interest in environmental releases of engineered gene drives due to recent proof of principle experiments with the CRISPR-Cas9 system as a drive mechanism. Release of modified organisms, however, is controversial, especially when the drive mechanism could theoretically alter all individuals of a species. Thus, it is desirable to have countermeasures to reverse a drive if a problem arises. Several genetic mechanisms for limiting or eliminating gene drives have been proposed and/or developed, including synthetic resistance, reversal drives, and immunizing reversal drives. While predictions about efficacy of these mechanisms have been optimistic, we lack detailed analyses of their expected dynamics. We develop a discrete time model for population genetics of a drive and proposed genetic countermeasures. Efficacy of drive reversal varies between countermeasures. For some parameter values, the model predicts unexpected behavior including polymorphic equilibria and oscillatory dynamics. The timing and number of released individuals containing a genetic countermeasure can substantially impact outcomes. The choice among countermeasures by researchers and regulators will depend on specific goals and population parameters of target populations. |*Clustered Regularly Interspaced Short Palindromic Repeats [MESH] |CRISPR-Associated Protein 9/*metabolism [MESH] |Gene Drive Technology/*methods [MESH] |Genetics, Population/*methods [MESH] |Models, Statistical [MESH] |Organisms, Genetically Modified/*genetics [MESH]Evaluating strategies for reversing CRISPR-Cas9 gene drives (epmc).pdf DeepDyve Pubget Overpricing