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2014 ; 30
(6
): 375-80
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Etiology and Complications of Portal Vein Thrombosis
#MMPMID26288604
Trebicka J
; Strassburg CP
Viszeralmedizin
2014[Dec]; 30
(6
): 375-80
PMID26288604
show ga
BACKGROUND: Portal venous occlusion represents a disorder with considerable
clinical relevance. The underlying causes of portal vein thrombosis (PVT) are
frequently multifactorial and include malignancies, progressive chronic liver
diseases, processes localized to the epigastrium and hepatobiliary system, and
acquired as well as inherited thrombophilia. The three main categorical groups
are malignant thrombosis, cirrhotic PVT, and non-malignant, non-cirrhotic PVT.
METHODS: Review of the literature. RESULTS: The site, the extent, its chronicity,
and the course of thromboses characterize a relatively heterogeneous clinical
presentation and the ensuing complications in affected patients. While the
occlusion of the extrahepatic portal and splenic vein likely provokes mainly
complications related to portal hypertension, mesenteric venous obstruction shows
a high rate of complications and mortality due to intestinal infarction.
Especially in patients with liver cirrhosis, special care is warranted with
regard to PVTs due to their pathogenetic role and influence on patient survival.
CONCLUSION: This article aims to summarize the current opinion on etiologies,
risk factors, and complications of this heterogeneous condition in adults.
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