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2012 ; 79
(5
): 637-643
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Estimating F-statistics: A historical view
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Weir BS
Philos Sci
2012[Dec]; 79
(5
): 637-643
PMID26405363
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Characterizing the genetic structure of populations is of importance to
evolutionary biology, to human disease gene mapping and to forensic science.
Sewall Wright introduced a set of "F-statistics" to describe population structure
in 1951 and he emphasized that these quantities were ratios of variances.
Responding to uncertainty over the best way to estimate F-statistics, Weir and
Cockerham published a method-of-moments set of estimators in 1984 (Evolution
38:1358-1370). This paper continues to be widely cited, with over 7,000 citations
to date. Some background to the publishing history of the Weir and Ccckerham
paper is given here, along with subsequent developments and a discussion of
current uses of Wright's F-statistics.