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10.1016/j.cell.2015.10.067

http://scihub22266oqcxt.onion/10.1016/j.cell.2015.10.067
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suck abstract from ncbi


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pmid26590417
      Cell 2015 ; 163 (5 ): 1064-1078
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  • Establishment and Dysfunction of the Blood-Brain Barrier #MMPMID26590417
  • Zhao Z ; Nelson AR ; Betsholtz C ; Zlokovic BV
  • Cell 2015[Nov]; 163 (5 ): 1064-1078 PMID26590417 show ga
  • Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.
  • |Animals [MESH]
  • |Astrocytes/metabolism [MESH]
  • |Blood-Brain Barrier/cytology/physiology/*physiopathology [MESH]
  • |Endothelial Cells/metabolism [MESH]
  • |Humans [MESH]
  • |Membrane Transport Proteins/metabolism [MESH]
  • |Nervous System Diseases/genetics/pathology/*physiopathology [MESH]


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