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10.1016/B978-0-444-63233-3.00015-4 http://scihub22266oqcxt.onion/10.1016/B978-0-444-63233-3.00015-4 C5898616!5898616 !29325613     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29325613 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Handb+Clin+Neurol 2018 ; 147 (ä): 229-239 Nephropedia Template TP {{tp|p=29325613 |t=2018. Essential tremor |pdf=|usr=}}{{29325613 }} gab.com Text Essential tremor JO: Handb Clin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=29325613 #FOAvip Essential tremor (ET) is one of the most common neurologic disorders, and genetic factors are thought to contribute significantly to disease etiology. There has been a relative lack of progress in understanding the genetic etiology of ET. This could reflect a number of factors, including the presence of substantial phenotypic and genotypic heterogeneity. Thus, a meticulous approach to phenotyping is important for genetic research. A lack of standardized phenotyping across studies and patient centers likely has contributed to the relative lack of success of genomewide association studies in ET. To dissect the genetic architecture of ET, whole-genome sequencing will likely be of value. This will allow specific hypotheses about the mode of inheritance and genetic architecture to be tested. A number of approaches still remain unexplored in ET genetics, including the contribution of copy number variants, uncommon moderate-effect alleles, rare variant large-effect alleles (including Mendelian and complex/polygenic modes of inheritance), de novo and gonadal mosaicism, epigenetic changes, and noncoding variation. Twit Text FOAVip Essential tremor ????Handb Clin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=29325613 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29325613 #FOAvip English Wikipedia <ref>{{Cite pmid|29325613 }}</ref> Essential tremor #MMPMID29325613 Clark LN ; Louis ED Handb Clin Neurol 2018[]; 147 (ä): 229-239 PMID29325613 show ga Essential tremor (ET) is one of the most common neurologic disorders, and genetic factors are thought to contribute significantly to disease etiology. There has been a relative lack of progress in understanding the genetic etiology of ET. This could reflect a number of factors, including the presence of substantial phenotypic and genotypic heterogeneity. Thus, a meticulous approach to phenotyping is important for genetic research. A lack of standardized phenotyping across studies and patient centers likely has contributed to the relative lack of success of genomewide association studies in ET. To dissect the genetic architecture of ET, whole-genome sequencing will likely be of value. This will allow specific hypotheses about the mode of inheritance and genetic architecture to be tested. A number of approaches still remain unexplored in ET genetics, including the contribution of copy number variants, uncommon moderate-effect alleles, rare variant large-effect alleles (including Mendelian and complex/polygenic modes of inheritance), de novo and gonadal mosaicism, epigenetic changes, and noncoding variation. |Essential Tremor/epidemiology/*genetics/*physiopathology [MESH] |Gene-Environment Interaction [MESH] |Genetic Predisposition to Disease/*genetics [MESH] |Genotype [MESH] |Humans [MESH]Essential tremor (epmc).pdf DeepDyve Pubget Overpricing