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2015 ; 2015
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Essential tremor
#MMPMID26678329
Zesiewicz TA
; Kuo SH
BMJ Clin Evid
2015[Dec]; 2015
(ä): ä PMID26678329
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INTRODUCTION: Essential tremor is one of the most common movement disorders in
the world, with prevalence in the general population of 0.4% to 3.9%. METHODS AND
OUTCOMES: We conducted a systematic overview, aiming to answer the following
clinical question: What are the effects of drug treatments in people with
essential tremor of the hand? We searched: Medline, Embase, The Cochrane Library,
and other important databases up to January 2014 (Clinical Evidence overviews are
updated periodically; please check our website for the most up-to-date version of
this overview). RESULTS: At this update, searching of electronic databases
retrieved 56 studies. After deduplication and removal of conference abstracts, 31
records were screened for inclusion in the overview. Appraisal of titles and
abstracts led to the exclusion of 18 studies and the further review of 13 full
publications. Of the 13 full articles evaluated, two RCTs were added at this
update. We performed a GRADE evaluation for 11 PICO combinations. CONCLUSIONS: In
this systematic overview, we categorised the efficacy for 13 interventions based
on information about the effectiveness and safety of alprazolam, beta-blockers
other than propranolol, botulinum A toxin-haemagglutinin complex, clonazepam,
diazepam, gabapentin, levetiracetam, lorazepam, phenobarbital, primidone,
propranolol, sodium oxybate, and topiramate.