10.1002/mds.26919 http://scihub22266oqcxt.onion/10.1002/mds.26919 C5359065!5359065
!28116753
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Mov+Disord
2017 ; 32
(3
): 325-331
Nephropedia Template TP gab.com Text Twit Text FOAVip Twit Text # English Wikipedia
Essential pitfalls in "essential" tremor
#MMPMID28116753
Espay AJ
; Lang AE
; Erro R
; Merola A
; Fasano A
; Berardelli A
; Bhatia KP
Mov Disord
2017[Mar]; 32
(3
): 325-331
PMID28116753
show ga
Although essential tremor has been considered the most common movement disorder,
it has largely remained a diagnosis of exclusion: many tremor and nontremor
features must be absent for the clinical diagnosis to stand. The clinical
features of "essential tremor" overlap with or may be part of other tremor
disorders and, not surprisingly, this prevalent familial disorder has remained
without a gene identified, without a consistent natural history, and without an
acceptable pathology or pathophysiologic underpinning. The collective evidence
suggests that under the rubric of essential tremor there exists multiple unique
diseases, some of which represent cerebellar dysfunction, but for which there is
no intrinsic "essence" other than a common oscillatory behavior on posture and
action. One approach may be to use the term essential tremor only as a
transitional node in the deep phenotyping of tremor disorders based on
historical, phenomenological, and neurophysiological features to facilitate its
etiologic diagnosis or serve for future gene- and biomarker-discovery efforts.
This approach deemphasizes essential tremor as a diagnostic entity and
facilitates the understanding of the underlying disorders to develop biologically
tailored diagnostic and therapeutic strategies. © 2017 International Parkinson
and Movement Disorder Society.
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