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10.1101/cshperspect.a011676 http://scihub22266oqcxt.onion/10.1101/cshperspect.a011676 C3683999!3683999 !23471474     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23471474 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cold+Spring+Harb+Perspect+Med 2013 ; 3 (4 ): a011676 Nephropedia Template TP {{tp|p=23471474 |t=2013. Erythroid heme biosynthesis and its disorders |pdf=|usr=}}{{23471474 }} gab.com Text Erythroid heme biosynthesis and its disorders JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=23471474 #FOAvip Heme, which is composed of iron and the small organic molecule protoporphyrin, is an essential component of hemoglobin as well as a variety of physiologically important hemoproteins. During erythropoiesis, heme synthesis is induced before, and is essential for, globin synthesis. Although all cells possess the ability to synthesize heme, there are distinct differences between regulation of the pathway in developing erythroid cells and all other types of cells. Disorders that compromise the ability of the developing red cell to synthesize heme can have profound medical implications. The biosynthetic pathway for heme and key regulatory features are reviewed herein, along with specific human genetic disorders that arise from defective heme synthesis such as X-linked sideroblastic anemia and erythropoietic protoporphyria. Twit Text FOAVip Erythroid heme biosynthesis and its disorders ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=23471474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23471474 #FOAvip English Wikipedia <ref>{{Cite pmid|23471474 }}</ref> Erythroid heme biosynthesis and its disorders #MMPMID23471474 Dailey HA ; Meissner PN Cold Spring Harb Perspect Med 2013[Apr]; 3 (4 ): a011676 PMID23471474 show ga Heme, which is composed of iron and the small organic molecule protoporphyrin, is an essential component of hemoglobin as well as a variety of physiologically important hemoproteins. During erythropoiesis, heme synthesis is induced before, and is essential for, globin synthesis. Although all cells possess the ability to synthesize heme, there are distinct differences between regulation of the pathway in developing erythroid cells and all other types of cells. Disorders that compromise the ability of the developing red cell to synthesize heme can have profound medical implications. The biosynthetic pathway for heme and key regulatory features are reviewed herein, along with specific human genetic disorders that arise from defective heme synthesis such as X-linked sideroblastic anemia and erythropoietic protoporphyria. |Coproporphyrinogens/metabolism [MESH] |Enzymes/*physiology [MESH] |Erythropoiesis/*physiology [MESH] |Hematologic Diseases/enzymology/*etiology [MESH] |Heme/*biosynthesis [MESH] |Humans [MESH]Erythroid heme biosynthesis and its disorders (epmc).pdf DeepDyve Pubget Overpricing