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2017 ; 8
(32
): 52690-52698
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Erectile dysfunction and the risk of prostate cancer
#MMPMID28881762
Lin WY
; Chang YH
; Lin CL
; Kao CH
; Wu HC
Oncotarget
2017[Aug]; 8
(32
): 52690-52698
PMID28881762
show ga
BACKGROUND: Prostate cancer (PCa) is the most commonly diagnosed malignancy and
the third leading cause of cancer death among men in developed countries. Because
some risk factors are common between erectile dysfunction (ED) and PCa, we
investigated the association between ED and subsequent PCa. METHODS: This
nationwide population-based cohort study used data from the Taiwan National
Health Insurance Research Database for the period 2000-2010. We identified
patients newly diagnosed with ED by using codes from the International
Classification of Diseases, Ninth Revision, Clinical Modification. RESULTS: In
total, 5858 and 23432 patients were enrolled in the ED and non-ED cohorts,
respectively. After adjustment for age, sex, and comorbidities, the overall
incidence densities of PCa were significantly higher in the ED cohort than in the
non-ED cohort, with an adjusted hazard ratio (aHR) of 1.19. The age-specific
relative risk of PCa was significantly higher for all age groups in the ED cohort
than in the non-ED cohort. Compared with patients without ED, those with organic
ED had a 1.27-fold higher risk of PCa. CONCLUSION: ED is a harbinger of PCa in
some men. Physicians should consider the possibility of occult PCa in patients
with ED regardless of age and comorbidities.
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