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2016 ; 18
(7
): 33
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Eradication of Helicobacter pylori Infection
#MMPMID27177639
Marcus EA
; Sachs G
; Scott DR
Curr Gastroenterol Rep
2016[Jul]; 18
(7
): 33
PMID27177639
show ga
Helicobacter pylori infects about 50 % of the world's population, causing at a
minimum chronic gastritis. A subset of infected patients will ultimately develop
gastric or duodenal ulcer disease, gastric adenocarcinoma, or MALT
(mucosa-associated lymphoid tissue) lymphoma. Eradication of H. pylori requires
complex regimens that include acid suppression and multiple antibiotics. The
efficacy of treatment using what were once considered standard regimens have
declined in recent years, mainly due to widespread development of antibiotic
resistance. Addition of bismuth to standard triple therapy regimens, use of
alternate antibiotics, or development of alternative regimens using known
therapies in novel combinations have improved treatment efficacy in specific
populations, but overall success of eradication remains less than ideal. Novel
regimens under investigation either in vivo or in vitro, involving increased acid
suppression ideally with fewer antibiotics or development of non-antibiotic
treatment targets, show promise for future therapy.