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http://scihub22266oqcxt.onion/ C4629788!4629788!25434353     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25434353.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Top+Med+Chem 2014 ; 14 (20): 2312-21 Nephropedia Template TP {{tp|p=25434353|t=2014. Epothilones: from discovery to clinical trials |pdf=|usr=}}{{25434353}} gab.com Text Epothilones: from discovery to clinical trials JO: Curr Top Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=25434353 #FOAvip Epothilones are natural compounds isolated from a myxobacterium at the beginning of the 1990s, and showed a remarkable anti-neoplastic activity. They act through the same mechanism of action of paclitaxel, by stabilizing microtubules and inducing apoptosis. Although, their chemical structure, simpler than taxanes, makes them more suitable for derivatization. Their interesting pharmacokinetic and bioavailabilty profiles, and the activity against paclitaxel-resistant cell lines make them interesting therapeutic agents. Here a brief historical perspective of epothilones is presented, since their isolation, the identification of their mechanism of action and activity, to the recent clinical trials. Twit Text FOAVip Epothilones: from discovery to clinical trials ????Curr Top Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=25434353 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25434353 #FOAvip English Wikipedia <ref>{{Cite pmid|25434353}}</ref> Epothilones: from discovery to clinical trials #MMPMID25434353 Forli S Curr Top Med Chem 2014[]; 14 (20): 2312-21 PMID25434353show ga Epothilones are natural compounds isolated from a myxobacterium at the beginning of the 1990s, and showed a remarkable anti-neoplastic activity. They act through the same mechanism of action of paclitaxel, by stabilizing microtubules and inducing apoptosis. Although, their chemical structure, simpler than taxanes, makes them more suitable for derivatization. Their interesting pharmacokinetic and bioavailabilty profiles, and the activity against paclitaxel-resistant cell lines make them interesting therapeutic agents. Here a brief historical perspective of epothilones is presented, since their isolation, the identification of their mechanism of action and activity, to the recent clinical trials. äEpothilones: from discovery to clinical trials (epmc).pdf DeepDyve Pubget Overpricing