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10.1007/s00441-016-2464-0 http://scihub22266oqcxt.onion/10.1007/s00441-016-2464-0 C5011038!5011038 !27461257     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27461257 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Tissue+Res 2016 ; 365 (3 ): 495-506 Nephropedia Template TP {{tp|p=27461257 |t=2016. Epithelial-mesenchymal transition in tissue repair and fibrosis |pdf=|usr=}}{{27461257 }} gab.com Text Epithelial-mesenchymal transition in tissue repair and fibrosis JO: Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=27461257 #FOAvip The epithelial-mesenchymal transition (EMT) describes the global process by which stationary epithelial cells undergo phenotypic changes, including the loss of cell-cell adhesion and apical-basal polarity, and acquire mesenchymal characteristics that confer migratory capacity. EMT and its converse, MET (mesenchymal-epithelial transition), are integral stages of many physiologic processes and, as such, are tightly coordinated by a host of molecular regulators. Converging lines of evidence have identified EMT as a component of cutaneous wound healing, during which otherwise stationary keratinocytes (the resident skin epithelial cells) migrate across the wound bed to restore the epidermal barrier. Moreover, EMT plays a role in the development of scarring and fibrosis, as the matrix-producing myofibroblasts arise from cells of the epithelial lineage in response to injury but are pathologically sustained instead of undergoing MET or apoptosis. In this review, we summarize the role of EMT in physiologic repair and pathologic fibrosis of tissues and organs. We conclude that further investigation into the contribution of EMT to the faulty repair of fibrotic wounds might identify components of EMT signaling as common therapeutic targets for impaired healing in many tissues. Graphical Abstract Model for injury-triggered EMT activation in physiologic wound repair (left) and fibrotic wound healing (right). Twit Text FOAVip Epithelial-mesenchymal transition in tissue repair and fibrosis ????Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=27461257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27461257 #FOAvip English Wikipedia <ref>{{Cite pmid|27461257 }}</ref> Epithelial-mesenchymal transition in tissue repair and fibrosis #MMPMID27461257 Stone RC ; Pastar I ; Ojeh N ; Chen V ; Liu S ; Garzon KI ; Tomic-Canic M Cell Tissue Res 2016[Sep]; 365 (3 ): 495-506 PMID27461257 show ga The epithelial-mesenchymal transition (EMT) describes the global process by which stationary epithelial cells undergo phenotypic changes, including the loss of cell-cell adhesion and apical-basal polarity, and acquire mesenchymal characteristics that confer migratory capacity. EMT and its converse, MET (mesenchymal-epithelial transition), are integral stages of many physiologic processes and, as such, are tightly coordinated by a host of molecular regulators. Converging lines of evidence have identified EMT as a component of cutaneous wound healing, during which otherwise stationary keratinocytes (the resident skin epithelial cells) migrate across the wound bed to restore the epidermal barrier. Moreover, EMT plays a role in the development of scarring and fibrosis, as the matrix-producing myofibroblasts arise from cells of the epithelial lineage in response to injury but are pathologically sustained instead of undergoing MET or apoptosis. In this review, we summarize the role of EMT in physiologic repair and pathologic fibrosis of tissues and organs. We conclude that further investigation into the contribution of EMT to the faulty repair of fibrotic wounds might identify components of EMT signaling as common therapeutic targets for impaired healing in many tissues. Graphical Abstract Model for injury-triggered EMT activation in physiologic wound repair (left) and fibrotic wound healing (right). |*Epithelial-Mesenchymal Transition [MESH] |*Wound Healing [MESH] |Animals [MESH] |Cicatrix/pathology [MESH] |Disease Models, Animal [MESH] |Fibrosis [MESH] |Humans [MESH]Epithelial-mesenchymal transition in tissue repair and fibrosis (epmc).pdf DeepDyve Pubget Overpricing