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10.1155/2015/792182 http://scihub22266oqcxt.onion/10.1155/2015/792182 C4575734!4575734 !26425122     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26425122 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Oncol 2015 ; 2015 (ä): 792182 Nephropedia Template TP {{tp|p=26425122 |t=2015. Epithelial to Mesenchymal Transition in a Clinical Perspective |pdf=|usr=}}{{26425122 }} gab.com Text Epithelial to Mesenchymal Transition in a Clinical Perspective JO: J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26425122 #FOAvip Tumor growth and metastatic dissemination rely on cellular plasticity. Among the different phenotypes acquired by cancer cells, epithelial to mesenchymal transition (EMT) has been extensively illustrated. Indeed, this transition allows an epithelial polarized cell to acquire a more mesenchymal phenotype with increased mobility and invasiveness. The role of EMT is quite clear during developmental stage. In the neoplastic context in many tumors EMT has been associated with a more aggressive tumor phenotype including local invasion and distant metastasis. EMT allows the cell to invade surrounding tissues and survive in the general circulation and through a stem cell phenotype grown in the host organ. The molecular pathways underlying EMT have also been clearly defined and their description is beyond the scope of this review. Here we will summarize and analyze the attempts made to block EMT in the therapeutic context. Indeed, till today, most of the studies are made in animal models. Few clinical trials are ongoing with no obvious benefits of EMT inhibitors yet. We point out the limitations of EMT targeting such tumor heterogeneity or the dynamics of EMT during disease progression. Twit Text FOAVip Epithelial to Mesenchymal Transition in a Clinical Perspective ????J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26425122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26425122 #FOAvip English Wikipedia <ref>{{Cite pmid|26425122 }}</ref> Epithelial to Mesenchymal Transition in a Clinical Perspective #MMPMID26425122 Pasquier J ; Abu-Kaoud N ; Al Thani H ; Rafii A J Oncol 2015[]; 2015 (ä): 792182 PMID26425122 show ga Tumor growth and metastatic dissemination rely on cellular plasticity. Among the different phenotypes acquired by cancer cells, epithelial to mesenchymal transition (EMT) has been extensively illustrated. Indeed, this transition allows an epithelial polarized cell to acquire a more mesenchymal phenotype with increased mobility and invasiveness. The role of EMT is quite clear during developmental stage. In the neoplastic context in many tumors EMT has been associated with a more aggressive tumor phenotype including local invasion and distant metastasis. EMT allows the cell to invade surrounding tissues and survive in the general circulation and through a stem cell phenotype grown in the host organ. The molecular pathways underlying EMT have also been clearly defined and their description is beyond the scope of this review. Here we will summarize and analyze the attempts made to block EMT in the therapeutic context. Indeed, till today, most of the studies are made in animal models. Few clinical trials are ongoing with no obvious benefits of EMT inhibitors yet. We point out the limitations of EMT targeting such tumor heterogeneity or the dynamics of EMT during disease progression. äEpithelial to Mesenchymal Transition in a Clinical Perspective (epmc).pdf DeepDyve Pubget Overpricing