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2015 ; 14
(1
): 1-7
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Epileptic syndromes: From clinic to genetic
#MMPMID25874049
Tafakhori A
; Aghamollaii V
; Faghihi-Kashani S
; Sarraf P
; Habibi L
Iran J Neurol
2015[Jan]; 14
(1
): 1-7
PMID25874049
show ga
Epilepsy is one of the most common neurological disorders. Studies have
demonstrated that genetic factors have a strong role in etiology of epilepsy.
Mutations in genes encoding ion channels, neurotransmitters and other proteins
involved in the neuronal biology have been recognized in different types of this
disease. Moreover, some chromosomal aberration including ring chromosomes will
result in epilepsy. In this review, we intend to highlight the role of molecular
genetic in etiology of epilepsy syndromes, inspect the most recent classification
of International League against Epilepsy and discuss the role of genetic
counseling and genetic testing in management of epilepsy syndromes. Furthermore,
we emphasize on collaboration of neurologists and geneticists to improve
diagnosis and management.