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2015 ; 2015
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Epilepsy (generalised seizures)
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BMJ Clin Evid
2015[Apr]; 2015
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INTRODUCTION: About 3% of people will be diagnosed with epilepsy during their
lifetime, but about 70% of people with epilepsy eventually go into remission.
METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the
following clinical question: What are the effects of additional treatments in
people with drug-resistant epilepsy characterised by generalised seizures? We
searched: Medline, Embase, The Cochrane Library, and other important databases up
to April 2014 (Clinical Evidence reviews are updated periodically; please check
our website for the most up-to-date version of this review). We included harms
alerts from relevant organisations such as the US Food and Drug Administration
(FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
RESULTS: We found four studies that met our inclusion criteria. We performed a
GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In
this systematic review we present information relating to the effectiveness and
safety on the addition of the following interventions: lacosamide, lamotrigine,
levetiracetam, perampanel, and zonisamide versus the addition of placebo.