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2015 ; 16
(3
): 175-82
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Epigenomic-basis of Preemptive Medicine for Neurodevelopmental Disorders
#MMPMID26069457
Kubota T
; Miyake K
; Hariya N
; Mochizuki K
Curr Genomics
2015[Jun]; 16
(3
): 175-82
PMID26069457
show ga
Neurodevelopmental disorders (NDs) are currently thought to be caused by either
genetic defects or various environmental factors. Recent studies have
demonstrated that congenital NDs can result not only from changes in DNA sequence
in neuronal genes but also from changes to the secondary epigenomic modifications
of DNA and histone proteins. Thus, epigenomic assays, as well as genomic assays,
are currently performed for diagnosis of the congenital NDs. It is recently known
that the epigenomic modifications can be altered by various environmental
factors, which potentially cause acquired NDs. Furthermore these alterations can
potentially be restored taking advantage of use of reversibility in epigenomics.
Therefore, epigenome-based early diagnosis and subsequent intervention, by using
drugs that restore epigenomic alterations, will open up a new era of preemptive
medicine for congenital and acquired NDs.