Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29535729
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Immunol
2018 ; 9
(ä): 355
Nephropedia Template TP
Sheppard EC
; Morrish RB
; Dillon MJ
; Leyland R
; Chahwan R
Front Immunol
2018[]; 9
(ä): 355
PMID29535729
show ga
Epigenetic modifications, such as histone modifications, DNA methylation status,
and non-coding RNAs (ncRNA), all contribute to antibody maturation during somatic
hypermutation (SHM) and class-switch recombination (CSR). Histone modifications
alter the chromatin landscape and, together with DNA primary and tertiary
structures, they help recruit Activation-Induced Cytidine Deaminase (AID) to the
immunoglobulin (Ig) locus. AID is a potent DNA mutator, which catalyzes
cytosine-to-uracil deamination on single-stranded DNA to create U:G mismatches.
It has been shown that alternate chromatin modifications, in concert with ncRNAs
and potentially DNA methylation, regulate AID recruitment and stabilize DNA
repair factors. We, hereby, assess the combination of these distinct
modifications and discuss how they contribute to initiating differential DNA
repair pathways at the Ig locus, which ultimately leads to enhanced
antibody-antigen binding affinity (SHM) or antibody isotype switching (CSR). We
will also highlight how misregulation of epigenomic regulation during DNA repair
can compromise antibody development and lead to a number of immunological
syndromes and cancer.
free
free
free
