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2016 ; 65
(11
): 1895-1905
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Epigenetics in liver disease: from biology to therapeutics
#MMPMID27624887
Hardy T
; Mann DA
Gut
2016[Nov]; 65
(11
): 1895-1905
PMID27624887
show ga
Knowledge of the fundamental epigenetic mechanisms governing gene expression and
cellular phenotype are sufficiently advanced that novel insights into the
epigenetic control of chronic liver disease are now emerging. Hepatologists are
in the process of shedding light on the roles played by DNA methylation,
histone/chromatin modifications and non-coding RNAs in specific liver
pathologies. Alongside these discoveries are advances in the technologies for the
detection and quantification of epigenetic biomarkers, either directly from
patient tissue or from body fluids. The premise for this review is to survey the
recent advances in the field of liver epigenetics and to explore their potential
for translation by industry and clinical hepatologists for the design of novel
therapeutics and diagnostic/prognostic biomarkers. In particular, we present
findings in the context of hepatocellular carcinoma, fibrosis and non-alcoholic
fatty liver disease, where there is urgent unmet need for new clinical
interventions and biomarkers.
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