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2018 ; 19
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): ä Nephropedia Template TP
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Epigenetics and MicroRNAs in Cancer
#MMPMID29401683
Ramassone A
; Pagotto S
; Veronese A
; Visone R
Int J Mol Sci
2018[Feb]; 19
(2
): ä PMID29401683
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The ability to reprogram the transcriptional circuitry by remodeling the
three-dimensional structure of the genome is exploited by cancer cells to promote
tumorigenesis. This reprogramming occurs because of hereditable chromatin
chemical modifications and the consequent formation of RNA-protein-DNA complexes
that represent the principal actors of the epigenetic phenomena. In this regard,
the deregulation of a transcribed non-coding RNA may be both cause and
consequence of a cancer-related epigenetic alteration. This review summarizes
recent findings that implicate microRNAs in the aberrant epigenetic regulation of
cancer cells.
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