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10.1016/j.yexcr.2014.09.013 http://scihub22266oqcxt.onion/10.1016/j.yexcr.2014.09.013 C4250347!4250347 !25261778     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25261778 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25261778 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Cell+Res 2014 ; 329 (2 ): 192-9 Nephropedia Template TP {{tp|p=25261778 |t=2014. Epigenetic regulation of hematopoietic stem cell aging |pdf=|usr=}}{{25261778 }} gab.com Text Epigenetic regulation of hematopoietic stem cell aging JO: Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25261778 #FOAvip Aging is invariably associated with alterations of the hematopoietic stem cell (HSC) compartment, including loss of functional capacity, altered clonal composition, and changes in lineage contribution. Although accumulation of DNA damage occurs during HSC aging, it is unlikely such consistent aging phenotypes could be solely attributed to changes in DNA integrity. Another mechanism by which heritable traits could contribute to the changes in the functional potential of aged HSCs is through alterations in the epigenetic landscape of adult stem cells. Indeed, recent studies on hematopoietic stem cells have suggested that altered epigenetic profiles are associated with HSC aging and play a key role in modulating the functional potential of HSCs at different stages during ontogeny. Even small changes of the epigenetic landscape can lead to robustly altered expression patterns, either directly by loss of regulatory control or through indirect, additive effects, ultimately leading to transcriptional changes of the stem cells. Potential drivers of such changes in the epigenetic landscape of aged HSCs include proliferative history, DNA damage, and deregulation of key epigenetic enzymes and complexes. This review will focus largely on the two most characterized epigenetic marks - DNA methylation and histone modifications - but will also discuss the potential role of non-coding RNAs in regulating HSC function during aging. Twit Text FOAVip Epigenetic regulation of hematopoietic stem cell aging ????Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25261778 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25261778 #FOAvip English Wikipedia <ref>{{Cite pmid|25261778 }}</ref> Epigenetic regulation of hematopoietic stem cell aging #MMPMID25261778 Beerman I ; Rossi DJ Exp Cell Res 2014[Dec]; 329 (2 ): 192-9 PMID25261778 show ga Aging is invariably associated with alterations of the hematopoietic stem cell (HSC) compartment, including loss of functional capacity, altered clonal composition, and changes in lineage contribution. Although accumulation of DNA damage occurs during HSC aging, it is unlikely such consistent aging phenotypes could be solely attributed to changes in DNA integrity. Another mechanism by which heritable traits could contribute to the changes in the functional potential of aged HSCs is through alterations in the epigenetic landscape of adult stem cells. Indeed, recent studies on hematopoietic stem cells have suggested that altered epigenetic profiles are associated with HSC aging and play a key role in modulating the functional potential of HSCs at different stages during ontogeny. Even small changes of the epigenetic landscape can lead to robustly altered expression patterns, either directly by loss of regulatory control or through indirect, additive effects, ultimately leading to transcriptional changes of the stem cells. Potential drivers of such changes in the epigenetic landscape of aged HSCs include proliferative history, DNA damage, and deregulation of key epigenetic enzymes and complexes. This review will focus largely on the two most characterized epigenetic marks - DNA methylation and histone modifications - but will also discuss the potential role of non-coding RNAs in regulating HSC function during aging. |*DNA Methylation [MESH] |Adult [MESH] |Animals [MESH] |Cellular Senescence/*physiology [MESH] |Epigenesis, Genetic/*genetics [MESH] |Hematopoietic Stem Cells/cytology/*metabolism [MESH] |Histones/*metabolism [MESH] |Humans [MESH]Epigenetic regulation of hematopoietic stem cell aging (epmc).pdf DeepDyve Pubget Overpricing