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2014 ; 35
(4
): 530-49
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Epigenetic regulation of estrogen-dependent memory
#MMPMID24878494
Fortress AM
; Frick KM
Front Neuroendocrinol
2014[Oct]; 35
(4
): 530-49
PMID24878494
show ga
Hippocampal memory formation is highly regulated by post-translational histone
modifications and DNA methylation. Accordingly, these epigenetic processes play a
major role in the effects of modulatory factors, such as sex steroid hormones, on
hippocampal memory. Our laboratory recently demonstrated that the ability of the
potent estrogen 17?-estradiol (E2) to enhance hippocampal-dependent novel object
recognition memory in ovariectomized female mice requires ERK-dependent histone
H3 acetylation and DNA methylation in the dorsal hippocampus. Although these data
provide valuable insight into the chromatin modifications that mediate the
memory-enhancing effects of E2, epigenetic regulation of gene expression is
enormously complex. Therefore, more research is needed to fully understand how E2
and other hormones employ epigenetic alterations to shape behavior. This review
discusses the epigenetic alterations shown thus far to regulate hippocampal
memory, briefly reviews the effects of E2 on hippocampal function, and describes
in detail our work on epigenetic regulation of estrogenic memory enhancement.
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