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10.2217/epi.14.75 http://scihub22266oqcxt.onion/10.2217/epi.14.75 C4422180!4422180 !25942533     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25942533 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25942533 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Epigenomics 2015 ; 7 (2 ): 235-45 Nephropedia Template TP {{tp|p=25942533 |t=2015. Epigenetic regulation of chronic pain |pdf=|usr=}}{{25942533 }} gab.com Text Epigenetic regulation of chronic pain JO: Epigenomics http://www.kidney.de/pget.php?&tw=1&pmid=25942533 #FOAvip Chronic pain arising from peripheral inflammation and tissue or nerve injury is a common clinical symptom. Although intensive research on the neurobiological mechanisms of chronic pain has been carried out during previous decades, this disorder is still poorly managed by current drugs such as opioids and nonsteroidal anti-inflammatory drugs. Inflammation, tissue injury and/or nerve injury-induced changes in gene expression in sensory neurons of the dorsal root ganglion, spinal cord dorsal horn and pain-associated brain regions are thought to participate in chronic pain genesis; however, how these changes occur is still elusive. Epigenetic modifications including DNA methylation and covalent histone modifications control gene expression. Recent studies have shown that peripheral noxious stimulation changes DNA methylation and histone modifications and that these changes may be related to the induction of pain hypersensitivity under chronic pain conditions. This review summarizes the current knowledge and progress in epigenetic research in chronic pain and discusses the potential role of epigenetic modifications as therapeutic antinociceptive targets in this disorder. Twit Text FOAVip Epigenetic regulation of chronic pain ????Epigenomics http://www.kidney.de/pget.php?&tw=1&pmid=25942533 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25942533 #FOAvip English Wikipedia <ref>{{Cite pmid|25942533 }}</ref> Epigenetic regulation of chronic pain #MMPMID25942533 Liang L ; Lutz BM ; Bekker A ; Tao YX Epigenomics 2015[]; 7 (2 ): 235-45 PMID25942533 show ga Chronic pain arising from peripheral inflammation and tissue or nerve injury is a common clinical symptom. Although intensive research on the neurobiological mechanisms of chronic pain has been carried out during previous decades, this disorder is still poorly managed by current drugs such as opioids and nonsteroidal anti-inflammatory drugs. Inflammation, tissue injury and/or nerve injury-induced changes in gene expression in sensory neurons of the dorsal root ganglion, spinal cord dorsal horn and pain-associated brain regions are thought to participate in chronic pain genesis; however, how these changes occur is still elusive. Epigenetic modifications including DNA methylation and covalent histone modifications control gene expression. Recent studies have shown that peripheral noxious stimulation changes DNA methylation and histone modifications and that these changes may be related to the induction of pain hypersensitivity under chronic pain conditions. This review summarizes the current knowledge and progress in epigenetic research in chronic pain and discusses the potential role of epigenetic modifications as therapeutic antinociceptive targets in this disorder. |*DNA Methylation [MESH] |*Epigenesis, Genetic [MESH] |Chronic Pain/*genetics/metabolism [MESH] |Histones/*metabolism [MESH]Epigenetic regulation of chronic pain (epmc).pdf DeepDyve Pubget Overpricing