Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24932182
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Allergy+Asthma+Clin+Immunol
2014 ; 10
(1
): 27
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Epigenetic regulation of asthma and allergic disease
#MMPMID24932182
Bégin P
; Nadeau KC
Allergy Asthma Clin Immunol
2014[]; 10
(1
): 27
PMID24932182
show ga
Epigenetics of asthma and allergic disease is a field that has expanded greatly
in the last decade. Previously thought only in terms of cell differentiation, it
is now evident the epigenetics regulate many processes. With T cell activation,
commitment toward an allergic phenotype is tightly regulated by DNA methylation
and histone modifications at the Th2 locus control region. When normal epigenetic
control is disturbed, either experimentally or by environmental exposures,
Th1/Th2 balance can be affected. Epigenetic marks are not only transferred to
daughter cells with cell replication but they can also be inherited through
generations. In animal models, with constant environmental pressure,
epigenetically determined phenotypes are amplified through generations and can
last up to 2 generations after the environment is back to normal. In this review
on the epigenetic regulation of asthma and allergic diseases we review basic
epigenetic mechanisms and discuss the epigenetic control of Th2 cells. We then
cover the transgenerational inheritance model of epigenetic traits and discuss
how this could relate the amplification of asthma and allergic disease prevalence
and severity through the last decades. Finally, we discuss recent epigenetic
association studies for allergic phenotypes and related environmental risk
factors as well as potential underlying mechanisms for these associations.
free
free
free
