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10.1126/science.aal2380 http://scihub22266oqcxt.onion/10.1126/science.aal2380 C5940341!5940341 !28729483     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28729483 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28729483 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2017 ; 357 (6348 ): ä Nephropedia Template TP {{tp|p=28729483 |t=2017. Epigenetic plasticity and the hallmarks of cancer |pdf=|usr=}}{{28729483 }} gab.com Text Epigenetic plasticity and the hallmarks of cancer JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=28729483 #FOAvip Chromatin and associated epigenetic mechanisms stabilize gene expression and cellular states while also facilitating appropriate responses to developmental or environmental cues. Genetic, environmental, or metabolic insults can induce overly restrictive or overly permissive epigenetic landscapes that contribute to pathogenesis of cancer and other diseases. Restrictive chromatin states may prevent appropriate induction of tumor suppressor programs or block differentiation. By contrast, permissive or "plastic" states may allow stochastic oncogene activation or nonphysiologic cell fate transitions. Whereas many stochastic events will be inconsequential "passengers," some will confer a fitness advantage to a cell and be selected as "drivers." We review the broad roles played by epigenetic aberrations in tumor initiation and evolution and their potential to give rise to all classic hallmarks of cancer. Twit Text FOAVip Epigenetic plasticity and the hallmarks of cancer ????Science http://www.kidney.de/pget.php?&tw=1&pmid=28729483 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28729483 #FOAvip English Wikipedia <ref>{{Cite pmid|28729483 }}</ref> Epigenetic plasticity and the hallmarks of cancer #MMPMID28729483 Flavahan WA ; Gaskell E ; Bernstein BE Science 2017[Jul]; 357 (6348 ): ä PMID28729483 show ga Chromatin and associated epigenetic mechanisms stabilize gene expression and cellular states while also facilitating appropriate responses to developmental or environmental cues. Genetic, environmental, or metabolic insults can induce overly restrictive or overly permissive epigenetic landscapes that contribute to pathogenesis of cancer and other diseases. Restrictive chromatin states may prevent appropriate induction of tumor suppressor programs or block differentiation. By contrast, permissive or "plastic" states may allow stochastic oncogene activation or nonphysiologic cell fate transitions. Whereas many stochastic events will be inconsequential "passengers," some will confer a fitness advantage to a cell and be selected as "drivers." We review the broad roles played by epigenetic aberrations in tumor initiation and evolution and their potential to give rise to all classic hallmarks of cancer. |*Epigenesis, Genetic [MESH] |*Oncogenes [MESH] |Carcinogenesis/*genetics [MESH] |Chromatin/chemistry/*metabolism [MESH] |DNA Methylation [MESH] |Humans [MESH]Epigenetic plasticity and the hallmarks of cancer (epmc).pdf DeepDyve Pubget Overpricing