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2015 ; 38
(4
): 237-46
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Epigenetic mechanisms of chronic pain
#MMPMID25765319
Descalzi G
; Ikegami D
; Ushijima T
; Nestler EJ
; Zachariou V
; Narita M
Trends Neurosci
2015[Apr]; 38
(4
): 237-46
PMID25765319
show ga
Neuropathic and inflammatory pain promote a large number of persisting
adaptations at the cellular and molecular level, allowing even transient tissue
or nerve damage to elicit changes in cells that contribute to the development of
chronic pain and associated symptoms. There is evidence that injury-induced
changes in chromatin structure drive stable changes in gene expression and neural
function, which may cause several symptoms, including allodynia, hyperalgesia,
anxiety, and depression. Recent findings on epigenetic changes in the spinal cord
and brain during chronic pain may guide fundamental advances in new treatments.
Here, we provide a brief overview of epigenetic regulation in the nervous system
and then discuss the still-limited literature that directly implicates epigenetic
modifications in chronic pain syndromes.
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