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2016 ; 17
(9
): 537-49
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Epigenetic mechanisms in neurogenesis
#MMPMID27334043
Yao B
; Christian KM
; He C
; Jin P
; Ming GL
; Song H
Nat Rev Neurosci
2016[Sep]; 17
(9
): 537-49
PMID27334043
show ga
In the embryonic and adult brain, neural stem cells proliferate and give rise to
neurons and glia through highly regulated processes. Epigenetic mechanisms -
including DNA and histone modifications, as well as regulation by non-coding RNAs
- have pivotal roles in different stages of neurogenesis. Aberrant epigenetic
regulation also contributes to the pathogenesis of various brain disorders. Here,
we review recent advances in our understanding of epigenetic regulation in
neurogenesis and its dysregulation in brain disorders, including discussion of
newly identified DNA cytosine modifications. We also briefly cover the emerging
field of epitranscriptomics, which involves modifications of mRNAs and long
non-coding RNAs.