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2018 ; 61
(7
): 808-814
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Epigenetic mechanism of survivin dysregulation in human cancer
#MMPMID29318497
Lyu H
; Huang J
; He Z
; Liu B
Sci China Life Sci
2018[Jul]; 61
(7
): 808-814
PMID29318497
show ga
Survivin (coding gene BIRC5) is a dual functional protein acting as a critical
inhibitor of apoptosis (IAP) and key regulator of cell cycle progression. It is
usually produced in embryonic tissues during development and undetectable in most
adult tissues. Overexpression of Survivin frequently occurs in various human
cancers and increased Survivin correlates with poor clinic outcome, tumor
recurrence, and therapeutic resistance. Because of its selective expression in
tumor, but not normal tissues, Survivin has been recognized as an attractive
target for cancer treatment. Although several therapeutic approaches targeting
Survivin are actively under clinical trials in human cancers, to date no
Survivin-targeted therapy has been approved for cancer treatment. Numerous
studies have devoted to uncovering the underlying mechanism resulting in Survivin
dysregulation at multiple levels, such as transcriptional and
post-transcriptional regulation. The current article provides a literature review
on the transcriptional and epigenetic regulation of Survivin expression in human
cancers. We focus on the impact of DNA methylation and histone modifications,
including specific lysine methylation, demethylation, and acetylation on the
expression of Survivin. The latest development of epigenetic approaches targeting
Survivin for cancer treatment are also discussed.
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