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10.1530/REP-15-0180 http://scihub22266oqcxt.onion/10.1530/REP-15-0180 C4529766!4529766 !26031750     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26031750 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26031750 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Reproduction 2015 ; 150 (3 ): R109-20 Nephropedia Template TP {{tp|p=26031750 |t=2015. Epigenetic dynamics during preimplantation development |pdf=|usr=}}{{26031750 }} gab.com Text Epigenetic dynamics during preimplantation development JO: Reproduction http://www.kidney.de/pget.php?&tw=1&pmid=26031750 #FOAvip Successful mammalian development requires descendants of single-cell zygotes to differentiate into diverse cell types even though they contain the same genetic material. Preimplantation dynamics are first driven by the necessity of reprogramming haploid parental epigenomes to reach a totipotent state. This process requires extensive erasure of epigenetic marks shortly after fertilization. During the few short days after formation of the zygote, epigenetic programs are established and are essential for the first lineage decisions and differentiation. Here we review the current understanding of DNA methylation and histone modification dynamics responsible for these early changes during mammalian preimplantation development. In particular, we highlight insights that have been gained through next-generation sequencing technologies comparing human embryos to other models as well as the recent discoveries of active DNA demethylation mechanisms at play during preimplantation. Twit Text FOAVip Epigenetic dynamics during preimplantation development ????Reproduction http://www.kidney.de/pget.php?&tw=1&pmid=26031750 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26031750 #FOAvip English Wikipedia <ref>{{Cite pmid|26031750 }}</ref> Epigenetic dynamics during preimplantation development #MMPMID26031750 Marcho C ; Cui W ; Mager J Reproduction 2015[Sep]; 150 (3 ): R109-20 PMID26031750 show ga Successful mammalian development requires descendants of single-cell zygotes to differentiate into diverse cell types even though they contain the same genetic material. Preimplantation dynamics are first driven by the necessity of reprogramming haploid parental epigenomes to reach a totipotent state. This process requires extensive erasure of epigenetic marks shortly after fertilization. During the few short days after formation of the zygote, epigenetic programs are established and are essential for the first lineage decisions and differentiation. Here we review the current understanding of DNA methylation and histone modification dynamics responsible for these early changes during mammalian preimplantation development. In particular, we highlight insights that have been gained through next-generation sequencing technologies comparing human embryos to other models as well as the recent discoveries of active DNA demethylation mechanisms at play during preimplantation. |*Epigenesis, Genetic [MESH] |Animals [MESH] |Blastocyst/*physiology [MESH] |Cell Differentiation/genetics [MESH] |Cell Lineage/genetics [MESH] |Chromatin Assembly and Disassembly [MESH] |DNA Methylation [MESH] |Embryonic Development/genetics [MESH] |Gene Expression Regulation, Developmental [MESH] |Genomic Imprinting [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Protein Processing, Post-Translational [MESH]Epigenetic dynamics during preimplantation development (epmc).pdf DeepDyve Pubget Overpricing