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1991 ; 82
(6
): 676-85
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Epigenetic control of tumor cell morphology
#MMPMID1649811
Horio K
; Yoshikura H
; Kawabata M
; Odawara T
; Sudo K
; Fujitani Y
; Lee G
; Iwamoto A
Jpn J Cancer Res
1991[Jun]; 82
(6
): 676-85
PMID1649811
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XC cell line derived from a single rat cell transformed by the Prague strain of
Rous sarcoma virus produced morphologically different colonies. Among them, two
distinct cell types consisting of thick, fusiform cells (L-type), and of flat,
polygonal cells (R-type) were apparent. By repeated subclonings, pure cultures,
L1 and R1, respectively, were obtained. These clones underwent morphological
conversion during prolonged culture; L-type colonies appeared in the R-type clone
and vice versa. The kinetic curve suggested that the conversion was
multi-stepped. When inoculated into nude mice, L-type cells produced much larger
tumors at a higher frequency than R-type cells, and the tumors induced by these
two clones were histologically different. The expression of v-src gene was higher
in L-type than in R-type cells at both mRNA and protein levels.
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