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10.1038/s41598-017-13916-w http://scihub22266oqcxt.onion/10.1038/s41598-017-13916-w C5676697!5676697 !29116102     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29116102 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 14642 Nephropedia Template TP {{tp|p=29116102 |t=2017. Epigenetic Transitions and Knotted Solitons in Stretched Chromatin |pdf=|usr=}}{{29116102 }} gab.com Text Epigenetic Transitions and Knotted Solitons in Stretched Chromatin JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29116102 #FOAvip The spreading and regulation of epigenetic marks on chromosomes is crucial to establish and maintain cellular identity. Nonetheless, the dynamic mechanism leading to the establishment and maintenance of tissue-specific, epigenetic pattern is still poorly understood. In this work we propose, and investigate in silico, a possible experimental strategy to illuminate the interplay between 3D chromatin structure and epigenetic dynamics. We consider a set-up where a reconstituted chromatin fibre is stretched at its two ends (e.g., by laser tweezers), while epigenetic enzymes (writers) and chromatin-binding proteins (readers) are flooded into the system. We show that, by tuning the stretching force and the binding affinity of the readers for chromatin, the fibre undergoes a sharp transition between a stretched, epigenetically disordered, state and a crumpled, epigenetically coherent, one. We further investigate the case in which a knot is tied along the chromatin fibre, and find that the knotted segment enhances local epigenetic order, giving rise to "epigenetic solitons" which travel and diffuse along chromatin. Our results point to an intriguing coupling between 3D chromatin topology and epigenetic dynamics, which may be investigated via single molecule experiments. Twit Text FOAVip Epigenetic Transitions and Knotted Solitons in Stretched Chromatin ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29116102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29116102 #FOAvip English Wikipedia <ref>{{Cite pmid|29116102 }}</ref> Epigenetic Transitions and Knotted Solitons in Stretched Chromatin #MMPMID29116102 Michieletto D ; Orlandini E ; Marenduzzo D Sci Rep 2017[Nov]; 7 (1 ): 14642 PMID29116102 show ga The spreading and regulation of epigenetic marks on chromosomes is crucial to establish and maintain cellular identity. Nonetheless, the dynamic mechanism leading to the establishment and maintenance of tissue-specific, epigenetic pattern is still poorly understood. In this work we propose, and investigate in silico, a possible experimental strategy to illuminate the interplay between 3D chromatin structure and epigenetic dynamics. We consider a set-up where a reconstituted chromatin fibre is stretched at its two ends (e.g., by laser tweezers), while epigenetic enzymes (writers) and chromatin-binding proteins (readers) are flooded into the system. We show that, by tuning the stretching force and the binding affinity of the readers for chromatin, the fibre undergoes a sharp transition between a stretched, epigenetically disordered, state and a crumpled, epigenetically coherent, one. We further investigate the case in which a knot is tied along the chromatin fibre, and find that the knotted segment enhances local epigenetic order, giving rise to "epigenetic solitons" which travel and diffuse along chromatin. Our results point to an intriguing coupling between 3D chromatin topology and epigenetic dynamics, which may be investigated via single molecule experiments. |*Algorithms [MESH] |*Chromatin [MESH] |*Epigenesis, Genetic [MESH] |*Gene Expression Regulation [MESH] |Chromosomes, Human [MESH] |Computer Simulation [MESH] |Humans [MESH] |Models, Biological [MESH]Epigenetic Transitions and Knotted Solitons in Stretched Chromatin (epmc).pdf DeepDyve Pubget Overpricing