Epigenetic Strategies to Boost Cancer Immunotherapies
#MMPMID28545238
Barrero MJ
Int J Mol Sci
2017[May]; 18
(6
): ? PMID28545238
show ga
Recently, immunotherapeutic approaches have shown impressive responses in a
subset of cancer patients. However, the rate of success is low and a large
percentage of treated patients do not experience clinical benefits. Therefore,
additional strategies are needed to improve responses and select responsive
patients. Emerging data suggest that epigenetic drugs can improve the responses
to immunotherapy. Understanding the mechanisms of resistance to immunotherapy and
the epigenetic events that take place during immune evasion is critical to
providing a rational combined use of immunotherapies and epigenetic drugs. This
review focuses in the epigenetic mechanisms involved in the responses to
immunotherapy and how current drugs that target epigenetic regulators impact on
them.
free
free
free
