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Epigenetic Modifications in Essential Hypertension
#MMPMID27023534
Wise IA
; Charchar FJ
Int J Mol Sci
2016[Mar]; 17
(4
): 451
PMID27023534
show ga
Essential hypertension (EH) is a complex, polygenic condition with no single
causative agent. Despite advances in our understanding of the pathophysiology of
EH, hypertension remains one of the world's leading public health problems.
Furthermore, there is increasing evidence that epigenetic modifications are as
important as genetic predisposition in the development of EH. Indeed, a complex
and interactive genetic and environmental system exists to determine an
individual's risk of EH. Epigenetics refers to all heritable changes to the
regulation of gene expression as well as chromatin remodelling, without
involvement of nucleotide sequence changes. Epigenetic modification is recognized
as an essential process in biology, but is now being investigated for its role in
the development of specific pathologic conditions, including EH. Epigenetic
research will provide insights into the pathogenesis of blood pressure regulation
that cannot be explained by classic Mendelian inheritance. This review
concentrates on epigenetic modifications to DNA structure, including the
influence of non-coding RNAs on hypertension development.
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