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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Interferon+Cytokine+Res
2016 ; 36
(7
): 454-61
Nephropedia Template TP
J Interferon Cytokine Res
2016[Jul]; 36
(7
): 454-61
PMID27379867
show ga
Toll-like receptors (TLRs) are major receptors of the host innate immune system
that recognize conserved pathogen-associated molecular patterns (PAMPs) of
invading microbes. Activation of TLR signaling culminates in the expression of
multiple genes in a coordinate and kinetically defined manner. In this review, we
summarize the current studies describing the chromatin landscape of
TLR-responsive inflammatory genes and how changes to this chromatin landscape
govern cell type-specific and temporal gene expression. We further elaborate
classical endotoxin tolerance and epigenetic mechanisms controlling tolerance and
interferon priming effects on inflammatory promoters.
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