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2015 ; 3
(1-2
): e974451
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Epidermal tight junctions in health and disease
#MMPMID25838981
Brandner JM
; Zorn-Kruppa M
; Yoshida T
; Moll I
; Beck LA
; De Benedetto A
Tissue Barriers
2015[]; 3
(1-2
): e974451
PMID25838981
show ga
The skin, the largest organ of the body, is an essential barrier that under
homeostatic conditions efficiently protects and/or minimizes damage from both
environmental (e.g. microorganisms, physical trauma, ultraviolet radiation) and
endogenous (e.g., cancers, inflammation) factors. This formidable barrier
function resides mainly in the epidermis, a dynamic, highly-stratified
epithelium. The epidermis has 2 major barrier structures: stratum corneum, the
outmost layer and tight junctions, intercellular junctions that seal adjacent
keratinocytes in the stratum granulosum, found below the stratum corneum. In
recent years there have been significant advances in our understanding of tight
junction function, composition and regulation. Herein we review what is known
about tight junctions in healthy skin and keratinocyte culture systems and
highlight the dynamic crosstalk observed between tight junctions and the
cutaneous immune system. Finally we discuss the preliminary observations
suggesting that tight junction function or protein expression may be relevant for
the pathogenesis of a number of common cutaneous inflammatory and neoplastic
conditions.
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