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2014 ; 4
(4
): a018218
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Epidermal barriers
#MMPMID24692192
Natsuga K
Cold Spring Harb Perspect Med
2014[Apr]; 4
(4
): a018218
PMID24692192
show ga
The epidermis functions as a physical barrier to the external environment and
works to prevent loss of water from the skin. Numerous factors have been
implicated in the formation of epidermal barriers, such as cornified envelopes,
corneocytes, lipids, junctional proteins, proteases, protease inhibitors,
antimicrobial peptides, and transcription factors. This review illustrates human
diseases (ichthyoses) and animal models in which the epidermal barrier is
disrupted or dysfunctional at steady state owing to ablation of one or more of
the above factors. These diseases and animal models help us to understand the
complicated mechanisms of epidermal barrier formation and give further insights
on epidermal development.