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10.1101/cshperspect.a018218

http://scihub22266oqcxt.onion/10.1101/cshperspect.a018218
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C3968788!3968788 !24692192
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suck abstract from ncbi


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pmid24692192
      Cold+Spring+Harb+Perspect+Med 2014 ; 4 (4 ): a018218
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  • Epidermal barriers #MMPMID24692192
  • Natsuga K
  • Cold Spring Harb Perspect Med 2014[Apr]; 4 (4 ): a018218 PMID24692192 show ga
  • The epidermis functions as a physical barrier to the external environment and works to prevent loss of water from the skin. Numerous factors have been implicated in the formation of epidermal barriers, such as cornified envelopes, corneocytes, lipids, junctional proteins, proteases, protease inhibitors, antimicrobial peptides, and transcription factors. This review illustrates human diseases (ichthyoses) and animal models in which the epidermal barrier is disrupted or dysfunctional at steady state owing to ablation of one or more of the above factors. These diseases and animal models help us to understand the complicated mechanisms of epidermal barrier formation and give further insights on epidermal development.
  • |Animals [MESH]
  • |Antimicrobial Cationic Peptides/metabolism [MESH]
  • |Biomarkers/metabolism [MESH]
  • |Epidermis/metabolism/*physiopathology [MESH]
  • |Humans [MESH]
  • |Ichthyosis/metabolism/*physiopathology [MESH]
  • |Lipid Metabolism [MESH]
  • |Serine Proteases/metabolism [MESH]
  • |Serine Proteinase Inhibitors/metabolism [MESH]
  • |Skin Physiological Phenomena [MESH]


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