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2014 ; 5
(ä): 82-90
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Epidemiology and pathogenesis of Bolivian hemorrhagic fever
#MMPMID24636947
Patterson M
; Grant A
; Paessler S
Curr Opin Virol
2014[Apr]; 5
(ä): 82-90
PMID24636947
show ga
The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV) is
reported to have a mortality rate of 25-35%. First identified in 1959, BHF was
the cause of a localized outbreak in San Joaquin until rodent population controls
were implemented in 1964. The rodent Calomys collosus was identified as the
primary vector and reservoir for the virus. Multiple animal models were
considered during the 1970s with the most human-like disease identified in Rhesus
macaques but minimal characterization of the pathogenesis has been published
since. A reemergence of reported BHF cases has been reported in recent years,
which necessitates the further study and development of a vaccine to prevent
future outbreaks.
|Animals
[MESH]
|Arenaviruses, New World/genetics/*pathogenicity/physiology
[MESH]