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Epidemiology and clinical manifestations of enteroaggregative Escherichia coli
#MMPMID24982324
Hebbelstrup Jensen B
; Olsen KE
; Struve C
; Krogfelt KA
; Petersen AM
Clin Microbiol Rev
2014[Jul]; 27
(3
): 614-30
PMID24982324
show ga
Enteroaggregative Escherichia coli (EAEC) represents a heterogeneous group of E.
coli strains. The pathogenicity and clinical relevance of these bacteria are
still controversial. In this review, we describe the clinical significance of
EAEC regarding patterns of infection in humans, transmission, reservoirs, and
symptoms. Manifestations associated with EAEC infection include watery diarrhea,
mucoid diarrhea, low-grade fever, nausea, tenesmus, and borborygmi. In early
studies, EAEC was considered to be an opportunistic pathogen associated with
diarrhea in HIV patients and in malnourished children in developing countries. In
recent studies, associations with traveler's diarrhea, the occurrence of diarrhea
cases in industrialized countries, and outbreaks of diarrhea in Europe and Asia
have been reported. In the spring of 2011, a large outbreak of hemolytic-uremic
syndrome (HUS) and hemorrhagic colitis occurred in Germany due to an EAEC O104:H4
strain, causing 54 deaths and 855 cases of HUS. This strain produces the potent
Shiga toxin along with the aggregative fimbriae. An outbreak of urinary tract
infection associated with EAEC in Copenhagen, Denmark, occurred in 1991; this
involved extensive production of biofilm, an important characteristic of the
pathogenicity of EAEC. However, the heterogeneity of EAEC continues to complicate
diagnostics and also our understanding of pathogenicity.
|Anti-Bacterial Agents/pharmacology/therapeutic use
[MESH]
free
free
free
