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Epidemiological characteristics of human prion diseases
#MMPMID27251305
Chen C
; Dong XP
Infect Dis Poverty
2016[Jun]; 5
(1
): 47
PMID27251305
show ga
Human prion diseases are a group of transmissible, progressive, and invariably
fatal neurodegenerative disorders, which include Kuru, Creutzfeldt-Jakob disease
(CJD), Gerstmann-Sträussler-Scheinker syndrome, and fatal familial insomnia.
Human prion diseases affect approximately 1-2 persons per million worldwide
annually, occurring in sporadic, inherited, and acquired forms. These diseases
have attracted both scientific and public attention not only because of their
mysterious pathogen, but also due to their considerable threat to public health
since the emergence of the variant CJD.There are still no specific therapeutic
and prophylactic interventions available for prion diseases, thus active
surveillance of human prion diseases is critical for disease control and
prevention. Since 1993, CJD surveillance systems have been established in many
countries and regions, and several long-term multinational cooperative projects
have been conducted.In this paper, the epidemiological characteristics of various
human prion diseases and the active surveillance systems pertaining to them in
different countries and regions are summarized and reviewed.
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