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2014 ; 32
(6
): 190-201
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Ephs and Ephrins in malignant gliomas
#MMPMID25418012
Ferluga S
; Debinski W
Growth Factors
2014[Dec]; 32
(6
): 190-201
PMID25418012
show ga
Eph receptor tyrosine kinases and the corresponding ephrin ligands play a pivotal
role in the glioma development and progression. Aberrant protein expression
levels of the Eph receptors and ephrins are often associated with higher tumor
grade and poor prognosis. Their function in tumorigenesis is complex due to the
intricate network of possible co-occurring interactions between neighboring tumor
cells and tumor microenvironment. Both Ephs and ephrins localize on the surface
of tumor cells, tumor vasculature, glioma stem cells, tumor cells infiltrating
brain, and immune cells infiltrating tumors. They can both promote and inhibit
tumorigenicity depending on the downstream forward and reverse signalling
generated. All the above-mentioned features make the Ephs/ephrins system an
intriguing candidate for the development of new therapeutic strategies in glioma
treatment. This review will give a general overview on the structure and the
function of Ephs and ephrins, with a particular emphasis on the state of the
knowledge of their role in malignant gliomas.
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