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2018 ; 2018
(ä): 9095275
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Eosinophils from Physiology to Disease: A Comprehensive Review
#MMPMID29619379
Ramirez GA
; Yacoub MR
; Ripa M
; Mannina D
; Cariddi A
; Saporiti N
; Ciceri F
; Castagna A
; Colombo G
; Dagna L
Biomed Res Int
2018[]; 2018
(ä): 9095275
PMID29619379
show ga
Despite being the second least represented granulocyte subpopulation in the
circulating blood, eosinophils are receiving a growing interest from the
scientific community, due to their complex pathophysiological role in a broad
range of local and systemic inflammatory diseases as well as in cancer and
thrombosis. Eosinophils are crucial for the control of parasitic infections, but
increasing evidence suggests that they are also involved in vital defensive tasks
against bacterial and viral pathogens including HIV. On the other side of the
coin, eosinophil potential to provide a strong defensive response against
invading microbes through the release of a large array of compounds can prove
toxic to the host tissues and dysregulate haemostasis. Increasing knowledge of
eosinophil biological behaviour is leading to major changes in established
paradigms for the classification and diagnosis of several allergic and autoimmune
diseases and has paved the way to a "golden age" of eosinophil-targeted agents.
In this review, we provide a comprehensive update on the pathophysiological role
of eosinophils in host defence, inflammation, and cancer and discuss potential
clinical implications in light of recent therapeutic advances.