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10.1016/j.addr.2014.08.012 http://scihub22266oqcxt.onion/10.1016/j.addr.2014.08.012 C4258440!4258440 !25174308     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25174308 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Drug+Deliv+Rev 2014 ; 79-80 (ä): 172-83 Nephropedia Template TP {{tp|p=25174308 |t=2014. Engineering strategies to mimic the glioblastoma microenvironment |pdf=|usr=}}{{25174308 }} gab.com Text Engineering strategies to mimic the glioblastoma microenvironment JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25174308 #FOAvip Glioblastoma multiforme (GBM) is the most common and deadly brain tumor, with a mean survival time of only 21months. Despite the dramatic improvements in our understanding of GBM fueled by recent revolutions in molecular and systems biology, treatment advances for GBM have progressed inadequately slowly, which is due in part to the wide cellular and molecular heterogeneity both across tumors and within a single tumor. Thus, there is increasing clinical interest in targeting cell-extrinsic factors as way of slowing or halting the progression of GBM. These cell-extrinsic factors, collectively termed the microenvironment, include the extracellular matrix, blood vessels, stromal cells that surround tumor cells, and all associated soluble and scaffold-bound signals. In this review, we will first describe the regulation of GBM tumors by these microenvironmental factors. Next, we will discuss the various in vitro approaches that have been exploited to recapitulate and model the GBM tumor microenvironment in vitro. We conclude by identifying future challenges and opportunities in this field, including the development of microenvironmental platforms amenable to high-throughput discovery and screening. We anticipate that these ongoing efforts will prove to be valuable both as enabling tools for accelerating our understanding of microenvironmental regulation in GBM and as foundations for next-generation molecular screening platforms that may serve as a conceptual bridge between traditional reductionist systems and animal or clinical studies. Twit Text FOAVip Engineering strategies to mimic the glioblastoma microenvironment ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25174308 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25174308 #FOAvip English Wikipedia <ref>{{Cite pmid|25174308 }}</ref> Engineering strategies to mimic the glioblastoma microenvironment #MMPMID25174308 Rape A ; Ananthanarayanan B ; Kumar S Adv Drug Deliv Rev 2014[Dec]; 79-80 (ä): 172-83 PMID25174308 show ga Glioblastoma multiforme (GBM) is the most common and deadly brain tumor, with a mean survival time of only 21months. Despite the dramatic improvements in our understanding of GBM fueled by recent revolutions in molecular and systems biology, treatment advances for GBM have progressed inadequately slowly, which is due in part to the wide cellular and molecular heterogeneity both across tumors and within a single tumor. Thus, there is increasing clinical interest in targeting cell-extrinsic factors as way of slowing or halting the progression of GBM. These cell-extrinsic factors, collectively termed the microenvironment, include the extracellular matrix, blood vessels, stromal cells that surround tumor cells, and all associated soluble and scaffold-bound signals. In this review, we will first describe the regulation of GBM tumors by these microenvironmental factors. Next, we will discuss the various in vitro approaches that have been exploited to recapitulate and model the GBM tumor microenvironment in vitro. We conclude by identifying future challenges and opportunities in this field, including the development of microenvironmental platforms amenable to high-throughput discovery and screening. We anticipate that these ongoing efforts will prove to be valuable both as enabling tools for accelerating our understanding of microenvironmental regulation in GBM and as foundations for next-generation molecular screening platforms that may serve as a conceptual bridge between traditional reductionist systems and animal or clinical studies. |Animals [MESH] |Brain Neoplasms/*pathology [MESH] |Extracellular Matrix/metabolism [MESH] |Glioblastoma/*pathology [MESH] |High-Throughput Screening Assays/methods [MESH] |Humans [MESH] |Models, Biological [MESH] |Molecular Biology/methods [MESH] |Survival Rate [MESH] |Systems Biology/methods [MESH] |Tissue Engineering/methods [MESH]Engineering strategies to mimic the glioblastoma microenvironment (epmc).pdf DeepDyve Pubget Overpricing