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10.3390/ijms18061122 http://scihub22266oqcxt.onion/10.3390/ijms18061122 C5485946!5485946 !28538671     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28538671 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28538671 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (6 ): ä Nephropedia Template TP {{tp|p=28538671 |t=2017. Engineering Exosomes for Cancer Therapy |pdf=|usr=}}{{28538671 }} gab.com Text Engineering Exosomes for Cancer Therapy JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28538671 #FOAvip There remains an urgent need for novel therapeutic strategies to treat metastatic cancer, which results in over 8 million deaths annually worldwide. Following secretion, exosomes are naturally taken up by cells, and capable of the stable transfer of drugs, therapeutic microRNAs and proteins. As knowledge of the biogenesis, release and uptake of exosomes continues to evolve, and thus also has interest in these extracellular vesicles as potential tumor-targeted vehicles for cancer therapy. The ability to engineer exosome content and migratory itinerary holds tremendous promise. Studies to date have employed viral and non-viral methods to engineer the parent cells to secrete modified exosomes, or alternatively, to directly manipulate exosome content following secretion. The majority of studies have demonstrated promising results, with decreased tumor cell invasion, migration and proliferation, along with enhanced immune response, cell death, and sensitivity to chemotherapy observed. The studies outlined in this review highlight the exciting potential for exosomes as therapeutic vehicles for cancer treatment. Successful implementation in the clinical setting will be dependent upon establishment of rigorous standards for exosome manipulation, isolation, and characterisation. Twit Text FOAVip Engineering Exosomes for Cancer Therapy ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28538671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28538671 #FOAvip English Wikipedia <ref>{{Cite pmid|28538671 }}</ref> Engineering Exosomes for Cancer Therapy #MMPMID28538671 Gilligan KE ; Dwyer RM Int J Mol Sci 2017[May]; 18 (6 ): ä PMID28538671 show ga There remains an urgent need for novel therapeutic strategies to treat metastatic cancer, which results in over 8 million deaths annually worldwide. Following secretion, exosomes are naturally taken up by cells, and capable of the stable transfer of drugs, therapeutic microRNAs and proteins. As knowledge of the biogenesis, release and uptake of exosomes continues to evolve, and thus also has interest in these extracellular vesicles as potential tumor-targeted vehicles for cancer therapy. The ability to engineer exosome content and migratory itinerary holds tremendous promise. Studies to date have employed viral and non-viral methods to engineer the parent cells to secrete modified exosomes, or alternatively, to directly manipulate exosome content following secretion. The majority of studies have demonstrated promising results, with decreased tumor cell invasion, migration and proliferation, along with enhanced immune response, cell death, and sensitivity to chemotherapy observed. The studies outlined in this review highlight the exciting potential for exosomes as therapeutic vehicles for cancer treatment. Successful implementation in the clinical setting will be dependent upon establishment of rigorous standards for exosome manipulation, isolation, and characterisation. |Animals [MESH] |Antineoplastic Agents/administration & dosage/therapeutic use [MESH] |Drug Delivery Systems/*methods [MESH] |Exosomes/*genetics/immunology [MESH] |Genetic Engineering/*methods [MESH] |Humans [MESH] |Immunotherapy/*methods [MESH] |MicroRNAs/administration & dosage/therapeutic use [MESH]Engineering Exosomes for Cancer Therapy (epmc).pdf DeepDyve Pubget Overpricing