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pmid28461969
      Acta+Naturae 2017 ; 9 (1 ): 6-14
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  • Engineering Chimeric Antigen Receptors #MMPMID28461969
  • Kulemzin SV ; Kuznetsova VV ; Mamonkin M ; Taranin AV ; Gorchakov AA
  • Acta Naturae 2017[Jan]; 9 (1 ): 6-14 PMID28461969 show ga
  • Chimeric antigen receptors (CARs) are recombinant protein molecules that redirect cytotoxic lymphocytes toward malignant and other target cells. The high feasibility of manufacturing CAR-modified lymphocytes for the therapy of cancer has spurred the development and optimization of new CAR T cells directed against a broad range of target antigens. In this review, we describe the main structural and functional elements constituting a CAR, discuss the roles of these elements in modulating the anti-tumor activity of CAR T cells, and highlight alternative approaches to CAR engineering.
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