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2017 ; 5
(ä): 22
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Engineering CAR-T cells
#MMPMID28652918
Zhang C
; Liu J
; Zhong JF
; Zhang X
Biomark Res
2017[]; 5
(ä): 22
PMID28652918
show ga
Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved
inspiring outcomes in patients with B cell malignancies, and are now being
investigated in other hematologic malignancies and solid tumors. CAR-T cells are
generated by the T cells from patients' or donors' blood. After the T cells are
expanded and genetically modified, they are reinfused into the patients. However,
many challenges still need to be resolved in order for this technology to gain
widespread adoption. In this review, we first discuss the structure and evolution
of chimeric antigen receptors. We then report on the tools used for production of
CAR-T cells. Finally, we address the challenges posed by CAR-T cells.