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10.1002/btm2.10042

http://scihub22266oqcxt.onion/10.1002/btm2.10042
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C5412866!5412866 !28516163
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suck abstract from ncbi

pmid28516163
      Bioeng+Transl+Med 2017 ; 2 (1 ): 17-30
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  • Engineered heparins as new anticoagulant drugs #MMPMID28516163
  • Vaidyanathan D ; Williams A ; Dordick JS ; Koffas MAG ; Linhardt RJ
  • Bioeng Transl Med 2017[Mar]; 2 (1 ): 17-30 PMID28516163 show ga
  • Heparin is an anionic polysaccharide that is widely used as a clinical anticoagulant. This glycosaminoglycan is prepared from animal tissues in metric ton quantities. Animal-sourced heparin is also widely used in the preparation of low molecular weight heparins that are gaining in popularity as a result of their improved pharmacological properties. The recent contamination of pharmaceutical heparin together with concerns about increasing demand for this life saving drug and the fragility of the heparin supply chain has led the scientific community to consider other potential sources for heparin. This review examines progress toward the preparation of engineered heparins through chemical synthesis, chemoenzymatic synthesis, and metabolic engineering.
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