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2014 ; 16
(6
): 713-33
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Engineered T cells for cancer treatment
#MMPMID24239105
Anurathapan U
; Leen AM
; Brenner MK
; Vera JF
Cytotherapy
2014[Jun]; 16
(6
): 713-33
PMID24239105
show ga
Adoptively transferred T cells have the capacity to traffic to distant tumor
sites, infiltrate fibrotic tissue and kill antigen-expressing tumor cells.
Various groups have investigated different genetic engineering strategies
designed to enhance tumor specificity, increase T cell potency, improve
proliferation, persistence or migratory capacity and increase safety. This review
focuses on recent developments in T cell engineering, discusses the clinical
application of these engineered cell products and outlines future prospects for
this therapeutic modality.
|*Cell Engineering
[MESH]
|Antigens, Neoplasm/biosynthesis
[MESH]
|Cell- and Tissue-Based Therapy
[MESH]
|Cytotoxicity, Immunologic
[MESH]
|Humans
[MESH]
|Immunotherapy, Adoptive
[MESH]
|Neoplasms/immunology/pathology/*therapy
[MESH]
|Recombinant Fusion Proteins/*genetics/therapeutic use
[MESH]