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10.1016/j.jcyt.2013.10.002

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C4013208!4013208 !24239105
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suck abstract from ncbi


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pmid24239105
      Cytotherapy 2014 ; 16 (6 ): 713-33
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  • Engineered T cells for cancer treatment #MMPMID24239105
  • Anurathapan U ; Leen AM ; Brenner MK ; Vera JF
  • Cytotherapy 2014[Jun]; 16 (6 ): 713-33 PMID24239105 show ga
  • Adoptively transferred T cells have the capacity to traffic to distant tumor sites, infiltrate fibrotic tissue and kill antigen-expressing tumor cells. Various groups have investigated different genetic engineering strategies designed to enhance tumor specificity, increase T cell potency, improve proliferation, persistence or migratory capacity and increase safety. This review focuses on recent developments in T cell engineering, discusses the clinical application of these engineered cell products and outlines future prospects for this therapeutic modality.
  • |*Cell Engineering [MESH]
  • |Antigens, Neoplasm/biosynthesis [MESH]
  • |Cell- and Tissue-Based Therapy [MESH]
  • |Cytotoxicity, Immunologic [MESH]
  • |Humans [MESH]
  • |Immunotherapy, Adoptive [MESH]
  • |Neoplasms/immunology/pathology/*therapy [MESH]
  • |Recombinant Fusion Proteins/*genetics/therapeutic use [MESH]


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