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2017 ; 46
(1
): 51-62
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Endothelin Signaling in Bone
#MMPMID28131136
Kristianto J
; Johnson MG
; Afzal R
; Blank RD
Endocrinol Metab Clin North Am
2017[Mar]; 46
(1
): 51-62
PMID28131136
show ga
The endothelin (ET) system includes 3 small peptide hormones and a pair of
G-protein-coupled receptors. This review first outlines the ET signaling pathway
and ET metabolism. Next, it summarizes the role of ET1 signaling in craniofacial
development. Then, it discusses observations relating ET signaling to
osteoblastic and other osteosclerotic processes in cancer. Finally, it describes
recent work in our laboratory that points to endothelin signaling as an upstream
mediator of WNT signaling, promoting bone matrix synthesis and mineralization. It
concludes with a statement of some remaining gaps in knowledge and proposals for
future research.